应用数学青年讨论班（午餐会）——Discovery and analysis of cell-fate landscape underlying single-cell transcriptome data
报告人：周沛劼（CMLR-PKU）
时间：2023-11-29 11:45-13:30（报告时间12:30-13:30，午餐从11:45开始提供）
地点：智华楼四元厅
摘要：
Single-cell sequencing technologies provide unprecedented resolution for studying the dynamic process of cell-state transitions during development and complex disease. These transitions can be modeled and understood as a multi-scale, stochastic dynamical system on a cell-fate landscape. This could significantly enhance the interpretability and robustness of data mining and biological discovery. However, analyzing high-dimensional, static single-cell RNA-sequencing (scRNA-seq) data with such models can be challenging due to the curse of dimensionality. In this talk, I will discuss how machine learning has enabled us to overcome the challenge and use dynamical system tools to analyze scRNA-seq data. I will first introduce the MuTrans algorithm, which uses a low-dimensional dynamical manifold to identify attractor basins and transition probabilities in snapshot data. I will also present the spliceJAC algorithms, which use non-equilibrium dynamical theory to analyze attractor stability within the landscape and identify transition-driving genes in gene expression and splicing processes. Finally, I will discuss our efforts to construct a time-varying landscape, which interpolates non-stationary time-series scRNA-seq data using Wasserstein-Fisher-Rao metric, unbalanced optimal transport and its neural network-based partial differential equation implementations. Overall, these approaches bridge the model-based and data-driven methods in the modeling and analysis of single-cell biology.
报告人简介：周沛劼，304am永利集团前沿交叉学科研究院国际机器学习研究中心助理教授，2010-2019年就读于304am永利集团计算数学专业，获得学士和博士学位，师从李铁军教授。毕业后在UC Irvine做博士后研究，任访问助理教授，合作导师Qing Nie。他的研究兴趣为数据驱动的计算系统生物学。
讨论班简介：304am永利集团应用数学青年讨论班 (Applied Mathematics Seminar for Youth) 是一个由304am永利集团卓越研究生计划组织的学术交流平台。该讨论班定期举办一系列读书会、学术报告，涵盖广泛的应用数学领域，旨在为应用数学领域的员工提供一个互相学习、交流和探讨的机会，促进员工们在该领域的学术成长和思维能力的培养。
报名问卷：我们提供午餐（从11:45开始），需要预定午餐的老师同学请填报名问卷 https://wj.qq.com/s2/13678589/96qs
